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Updated: Jun 13, 2026
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Published on: November 8, 2016
Changes in the Metabolism of GD2-Specific Murine CAR-T Cells After Co-Culturing with Melanoma
Aleksey Bulygin1, Julia Philippova1, Nikita Basov2,3
1Laboratory of Molecular Immunology, Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology, 630099 Novosibirsk, Russia.
Abstract:
Immunotherapy with the use of induced CAR-T cells is an effective method of cancer suppression in close to in vivo conditions. The question of the nature of metabolism of CAR-T cells in the conditions of fighting not against single cancer cells, but against tumor cells, remains relevant. Our studies have shown the metabolomic profile of mouse GD2-specific CAR-T cells upon contact with B78-21 melanoma tumor cells and upon exposure to B-21 melanoma 3D spheroid structures.
