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Updated: Jun 13, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

A Multi-Locus and Machine Learning-Based Assessment of SNCA Variants in Alzheimer's Disease

Hatice Segmen1, Mustafa Yildiz2

  • 1Department of Neurology, Kanuni Sultan Suleyman Training and Research Hospital, Saglik Bilimleri University, 34303 Istanbul, Türkiye.

International Journal of Molecular Sciences
|June 12, 2026
PubMed
Summary

This study explored single nucleotide polymorphisms (SNPs) in the SNCA gene and their link to Alzheimer's disease (AD). Some SNCA variants showed exploratory associations with AD risk, but clinical factors were stronger predictors.

Keywords:
Alzheimer’s diseaseSNCA genealpha-synucleinrs10005233rs2583988rs2619363rs2619364

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