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Transcriptomic Profiling of Psoriatic Lesions by Tape-Stripping Reveals Site-Specific Differences
Maruška Marovt1,2, Martina Krušič2, Mario Gorenjak2
1Department of Dermatovenerology, University Medical Centre Maribor, 2000 Maribor, Slovenia.
Journal of Clinical Medicine
|June 12, 2026
Summary
Psoriasis treatment varies by body location due to distinct skin gene expression. Understanding these site-specific molecular differences can lead to personalized therapies for plaque psoriasis.
Area of Science:
- Dermatology
- Genomics
- Immunology
Background:
- Psoriasis, particularly plaque psoriasis, is a common chronic immune-mediated skin disease.
- While biologics improve outcomes, some body areas show resistance to treatment.
- Treatment response variability suggests anatomical site-specific differences in psoriasis.
Purpose of the Study:
- To investigate anatomical site-specific differences in the skin transcriptome of psoriasis plaques.
- To identify molecular signatures associated with lesion location in psoriasis.
- To explore potential reasons for treatment resistance in specific body regions.
Main Methods:
- Collected 44 psoriatic plaque samples from scalp, trunk, upper, and lower extremities using tape-stripping.
- Performed differential gene expression and gene ontology analysis.
- Utilized an inflammation-controlled approach with 80 healthy skin samples (GSE54456) for comparison.
Main Results:
- Identified distinct molecular signatures and biological pathways across different anatomical sites.
- Observed differential expression of SERPINB7 and specific microRNAs (miR-205, miR-203a).
- Highlighted psoriasis heterogeneity, suggesting site-specific mechanisms influence disease and treatment response.
Conclusions:
- Psoriasis exhibits anatomical site-specific transcriptomic differences.
- These findings underscore the need for personalized, site-specific therapeutic strategies.
- Further validation through larger studies with paired patient samples is recommended.
