Does Chronological Age Adequately Stratify Perioperative Risk? A Prospective Multicenter Cohort Study Using Frailty...

Background: Chronological age remains deeply embedded in perioperative risk assessment because it is readily available and intuitively associated with adverse outcomes. In clinical practice, however, patients of similar age frequently experience markedly different postoperative trajectories, suggesting that physiological reserve may more accurately reflect vulnerability to surgical stress than years lived alone. We therefore investigated whether age-based stratification inadequately captures perioperative vulnerability when compared with functional phenotyping based on frailty status and baseline handgrip strength (HGS). Methods: We conducted a prospective multicenter observational cohort study including 223 adults undergoing elective abdominal surgery between January 2023 and June 2025. Chronological age was evaluated both continuously and using a conventional threshold (<70 vs. ≥70 years). Physiological reserve was characterized using a phenotype-based frailty model (fit, pre-frail, frail) and baseline HGS measured at hospital admission. Prolonged hospitalization, defined a priori as length of stay (LOS) > 10 days, was used as a pragmatic clinical benchmark. Cross-classification analyses, logistic regression, and receiver operating characteristic (ROC) curve analyses were performed to compare the discriminatory performance of chronological age, frailty phenotype, and HGS. Results: Substantial discordance was observed between chronological age and frailty phenotype. Among patients younger than 70 years, 7.7% met criteria for frailty, whereas 58.0% of patients aged ≥70 years were classified as fit or pre-frail. Prolonged hospitalization occurred in 48 patients (21.5%) and varied markedly according to frailty status within each age group. Frail patients younger than 70 years demonstrated higher rates of prolonged LOS than fit older patients (40.0% vs. 10.5%). Chronological age demonstrated limited discrimination for prolonged hospitalization (AUC 0.579), while the ≥70-year threshold showed poor discriminatory performance (AUC 0.541). Frailty phenotype demonstrated improved discrimination (AUC 0.679), whereas the combined multivariable model integrating age, frailty, HGS, sex, and oncologic indication achieved good discriminatory performance (AUC 0.810). In multivariable analyses, frailty remained independently associated with prolonged LOS, whereas chronological age did not. Conclusions: Chronological age alone demonstrated limited discriminatory performance for perioperative risk stratification. Functional phenotyping based primarily on frailty status, complemented by objective functional measures such as HGS, may better capture physiological reserve and support more individualized, function-centered perioperative assessment in abdominal surgery.