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Related Experiment Video

Updated: Jun 13, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

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Published on: June 8, 2020

Fecal Immunochemical Test and Multitarget Stool DNA Testing for Colorectal Cancer Screening in Real-World Practice: A

Ashish Sharma1, Angad Tiwari2, Ishita Ray3

  • 1Department of Internal Medicine, Yale New Haven Hospital, New Haven, CT 06510, USA.

Journal of Clinical Medicine
|June 12, 2026
PubMed
Summary

Fecal immunochemical tests (FIT) and multitarget stool DNA (mt-sDNA) are effective colorectal cancer (CRC) screening tools. These non-invasive methods should be viewed as complementary, not competing, for optimal CRC prevention.

Keywords:
colorectal cancerfecal immunochemical test (FIT)multitarget stool DNA test (mt-sDNA)preventive oncology

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Published on: September 25, 2011

Area of Science:

  • Oncology
  • Gastroenterology
  • Public Health

Background:

  • Colorectal cancer (CRC) presents a significant global health burden with high mortality rates.
  • Effective screening strategies are crucial for CRC prevention and early detection.
  • Non-invasive stool-based tests, including FIT and mt-sDNA, offer promising alternatives to colonoscopy for average-risk individuals.

Purpose of the Study:

  • To conduct a narrative literature review comparing fecal immunochemical testing (FIT) and multitarget stool DNA (mt-sDNA) for colorectal cancer screening.
  • To evaluate diagnostic accuracy, cost-effectiveness, adherence, and implementation outcomes of FIT versus mt-sDNA.
  • To assess real-world validity factors influencing the effectiveness of stool-based CRC screening.

Main Methods:

  • Extensive narrative literature review of research published between 2020 and 2025.
  • Comparative analysis of FIT and mt-sDNA tests based on diagnostic accuracy (sensitivity, specificity), cost-effectiveness, adherence rates, and implementation outcomes.
  • Examination of post-test follow-up requirements and potential healthcare disparities.

Main Results:

  • Evidence from randomized controlled trials supports FIT and mt-sDNA for CRC screening.
  • Real-world effectiveness is influenced by adherence, follow-up, healthcare costs, accessibility, and system capacity.
  • Both FIT and mt-sDNA demonstrate varying diagnostic accuracies and cost-effectiveness profiles.

Conclusions:

  • FIT and mt-sDNA should be considered complementary, not competing, screening technologies for colorectal cancer.
  • Optimal effectiveness relies on appropriate patient selection and robust, system-level implementation.
  • Integrating strategic test selection with strong follow-up infrastructure is essential for population-wide CRC prevention benefits.