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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which indirectly block calcium...

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Sex-disaggregated data in hypertrophic cardiomyopathy: a targeted literature review, meta-analysis and primary cohort study.

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Real-World Evaluation of Guideline-Directed Treatments in Patients With Obstructive Hypertrophic Cardiomyopathy in Germany.

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Related Experiment Video

Updated: Jun 13, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Use of Disopyramide in Obstructive Hypertrophic Cardiomyopathy: A European Insight.

Philippe Charron1, Faizel Osman2,3, Jean-Noel Trochu4

  • 1Department of Cardiology & Department of Genetics, Hôpital Universitaire Pitié-Salpêtrière, IHU-ICAN, INSERM 1166, AP-HP, Sorbonne Université, 75013 Paris, France.

Journal of Clinical Medicine
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Disopyramide use is very low in obstructive hypertrophic cardiomyopathy (HCM) patients across England and France, with minimal uptake in Germany. Barriers like cost and availability may limit its use, potentially increasing adoption of alternative therapies.

Keywords:
disopyramideguideline-directed treatmenthypertrophic cardiomyopathyleft ventricular outflow tract obstructionobstructiontherapy

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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
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Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

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Last Updated: Jun 13, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Obstructive hypertrophic cardiomyopathy (HCM) guidelines recommend disopyramide as an add-on therapy for persistent symptoms.
  • Real-world data on disopyramide use beyond single centers are scarce.
  • This study evaluated disopyramide utilization in obstructive HCM before cardiac myosin inhibitors became available.

Purpose of the Study:

  • To quantify the use of disopyramide in obstructive HCM patients in England, France, and Germany.
  • To identify potential barriers to disopyramide prescription in routine clinical practice.

Main Methods:

  • Retrospective analysis of national healthcare databases from England, France, and Germany (2010-2019).
  • Inclusion criteria: adults (18+) diagnosed with obstructive HCM or HCM requiring septal reduction therapy.
  • Disopyramide usage defined as at least one prescription per patient annually.

Main Results:

  • Identified 3730 (England), 6823 (France), and 1141 (Germany) obstructive HCM patients.
  • Annual disopyramide use was 4.7%-5.6% in England and 1.7%-2.6% in France.
  • No reimbursed disopyramide use was recorded in Germany during the study period.

Conclusions:

  • Disopyramide use in obstructive HCM is notably low across the studied European countries.
  • Potential contributing factors include treatment-related issues, drug availability, and lack of reimbursement.
  • These limitations may encourage the adoption of alternative guideline-recommended therapies for obstructive HCM.