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Updated: Jun 13, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Pediatric ACL Injuries: A Current Concepts Review.

Caroline de Pesters^1,2, Tom Piscaer², Muhammad Deryl Ivansyah³

¹Department of Orthopaedics, Children's Hospital, Toulouse University Hospital, 330 Avenue de Grande Bretagne, 31300 Toulouse, France.

Journal of Clinical Medicine

|June 12, 2026

Summary

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Pediatric anterior cruciate ligament (ACL) tears require specialized care due to unique growth considerations. Management is complex, with anterior cruciate ligament reconstruction (ACLR) facing challenges but remaining the standard of care.

Area of Science:

Orthopedics
Pediatric Sports Medicine
Biomechanics

Background:

Pediatric anterior cruciate ligament (ACL) injuries present unique challenges due to skeletal immaturity and early sports specialization.
These injuries are distinct from adult ACL tears and necessitate tailored management strategies.

Purpose of the Study:

To review diagnostic protocols for pediatric ACL injuries.
To examine pediatric-specific knee morphology and neuromechanical risk factors.
To evaluate management strategies, including conservative care, repair, reconstruction, rehabilitation, and prevention.

Main Methods:

Systematic review of current literature on pediatric ACL injury.
Synthesis of diagnostic findings, risk factors, and treatment modalities.

Keywords:

ACL reconstruction ACL repair conservative management graft remodeling growth disturbances knee morphology pediatric ACL prevention sports medicine

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Last Updated: Jun 13, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Analysis of surgical techniques, rehabilitation protocols, and prevention programs.

Main Results:

Pediatric ACL diagnosis requires careful interpretation of specific clinical and imaging findings.
Management balances stability restoration with bone growth preservation; ACL reconstruction (ACLR) is the gold standard over repair.
ACLR faces challenges like growth disturbance and graft failure, highlighting the need for tailored rehabilitation and prevention.

Conclusions:

Managing pediatric ACL ruptures is complex, with significant evidence gaps.
Refined management strategies and prospective pediatric studies are crucial for improving outcomes.