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The Evolving Landscape of Systemic Therapy for Liposarcoma.
Hee Kyung Kim1,2,3, Akshat Sarkari1,2, Warren A Chow1,2
1Chao Family Comprehensive Cancer Center, University of California, Orange, CA 92868, USA.
Cancers
|June 12, 2026
Summary
Advanced liposarcoma is difficult to treat with chemotherapy. This review covers current systemic therapies and new subtype-driven strategies, focusing on molecular classification for personalized treatment.
Area of Science:
- Oncology
- Medical Genetics
Background:
- Liposarcoma is a diverse mesenchymal malignancy with challenging advanced/metastatic disease.
- Limited efficacy of traditional chemotherapy necessitates novel therapeutic approaches.
Purpose of the Study:
- To review evidence-based systemic therapies for advanced liposarcoma.
- To highlight recent advances in subtype-driven treatment strategies.
Main Methods:
- Review of clinical trials for anthracyclines, trabectedin, eribulin, and selinexor.
- Discussion of targeted therapies (MDM2, CDK4 amplification) and immunotherapy (checkpoint inhibitors, T-cell receptor therapies).
Main Results:
- Molecular classification (histologic and genomic) is crucial for guiding treatment selection.
- Biomarker-driven strategies and combination therapies are advancing personalized medicine.
Conclusions:
- Personalized treatment approaches are evolving for advanced liposarcoma.
- Continued progress in biomarker discovery and rational combinations will improve patient outcomes.
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