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Updated: Jun 13, 2026

Preparation of Naringenin Solution for In Vivo Application
08:18

Preparation of Naringenin Solution for In Vivo Application

Published on: August 10, 2021

Naringenin, a Food-Derived Flavanone, Suppresses ITGA11-Associated Gastric Cancer Progression via the

Qiang Li1, Guiyang Ye1, Fangfang Chen2

  • 1Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Cancers
|June 12, 2026
PubMed

Insights

Integrin alpha-11 (ITGA11) drives gastric cancer (GC) progression by altering the extracellular matrix. The compound Naringenin effectively inhibits ITGA11 activity, offering a potential therapeutic strategy for GC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Gastric cancer (GC) is a major global health concern, with poor outcomes often linked to extracellular matrix (ECM) dysregulation.
  • The precise mechanisms by which GC cells interact with and are influenced by the ECM are not fully understood.
  • Aberrant ECM remodeling is a critical factor in GC progression.

Purpose of the Study:

  • To investigate the role of Integrin alpha-11 (ITGA11) in GC progression.
  • To explore the association between ITGA11 expression and clinical outcomes in GC patients.
  • To assess the potential of Naringenin as a therapeutic agent targeting the ITGA11 pathway in GC.

Main Methods:

  • Integrative bioinformatics analyses were used to identify ITGA11.
  • ITGA11 expression, clinical significance, and ECM associations were evaluated in GC tissues and public datasets.
  • In vitro and in vivo assays examined ITGA11 function and its regulation of the FAK/PI3K/AKT/mTOR pathway. Naringenin's inhibitory effects were assessed.

Main Results:

  • ITGA11 was found to be upregulated in GC tissues, correlating with aggressive features and poor survival.
  • ITGA11 promoted malignant phenotypes in GC cells both in vitro and in vivo.
  • Naringenin demonstrated potential interaction with ITGA11, reducing its levels, suppressing pathway activation, and inhibiting GC cell malignancy.

Conclusions:

  • ITGA11 serves as a potential prognostic biomarker and functional driver in gastric cancer.
  • Naringenin shows promise as a bioactive compound for targeting the ITGA11/FAK/PI3K/AKT/mTOR axis in GC therapy.
Keywords:
FAK/PI3K/AKT/mTOR axisITGA11Naringeningastric cancer

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