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Targeted Therapies in Neuroblastoma: A History and a View to the Future

Nilay Shah1,2

  • 1Division of Hematology/Oncology/BMT, Nationwide Children's Hospital, Columbus, OH 43205, USA.

Cancers
|June 12, 2026
PubMed

Insights

Neuroblastomas are aggressive pediatric cancers causing significant deaths despite treatment. Targeted therapies, including isotretinoin and anti-GD2 antibodies, offer improved survival and reduced side effects for neuroblastoma patients.

Area of Science:

  • Pediatric Oncology
  • Cancer Therapeutics
  • Molecular Oncology

Background:

  • Neuroblastomas account for 8% of childhood cancer diagnoses and 14% of cancer-related deaths.
  • Aggressive multimodal treatments lead to significant long-term sequelae in survivors.
  • Targeted therapies are crucial for improving survival and reducing treatment-related harm.
Keywords:
GD2MYCNdifferentiationneuroblastomapediatric oncologyprecision medicinetargeted therapies

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