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Related Experiment Video

Updated: Jun 27, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

A Simple Admission-Based Score for Early Mortality Risk Stratification in Non-Shock Sepsis: A Pilot Study.

Simona Maria Borta1,2, Romana Olivia Popetiu1,2, Larisa Alexandra Rus1,2

  • 1Department of Internal Medicine, Faculty of Medicine, "Vasile Goldiș" Western University of Arad, Bulevardul Revoluției 94, 310025 Arad, Romania.

Diagnostics (Basel, Switzerland)
|June 12, 2026
PubMed
Summary

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This study developed a simple Sepsis CORE score using atrial fibrillation and creatinine to predict mortality in non-shock sepsis patients. The score aids early triage and risk stratification for better patient outcomes.

Area of Science:

  • Critical Care Medicine
  • Internal Medicine
  • Biomarkers and Diagnostics

Background:

  • Early risk stratification for non-shock sepsis patients is challenging due to potential clinical stability despite deterioration.
  • Existing methods struggle to identify patients at high risk of in-hospital mortality upon admission.
  • A need exists for a simple, clinically applicable triage score for non-shock sepsis.

Purpose of the Study:

  • To identify admission-based predictors of in-hospital mortality in non-shock sepsis patients.
  • To derive a simple, clinically applicable triage score for early risk stratification.
  • To integrate key pathophysiological domains into a predictive model.

Main Methods:

  • Prospective pilot study of 182 adult non-shock sepsis patients.
Keywords:
atrial fibrillationcreatinineearly diagnosismortalitypresepsinrisk assessmentsepsis

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Last Updated: Jun 27, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
10:38

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Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
05:28

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis

Published on: December 9, 2022

  • Analysis of cardiovascular, renal, immune-inflammatory, metabolic, hepatic, and comorbidity burden markers.
  • Logistic and LASSO regression with bootstrap validation to identify independent predictors.

    • Main Results:

    • Atrial fibrillation and creatinine were independent predictors of in-hospital mortality.
    • A presepsin-based model achieved an AUC of 0.843, with high sensitivity and specificity.
    • The Sepsis CORE score demonstrated progressive risk stratification, correlating with mortality rates.

    Conclusions:

    • The Sepsis CORE score integrates cardiovascular, renal, and immune domains for effective risk stratification.
    • The score offers a high negative predictive value, supporting early triage of non-shock sepsis patients.
    • External validation is recommended to confirm the score's generalizability.