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Updated: Jun 13, 2026

CT-guided Preoperative Localization of Pulmonary Nodules Using a Glucose Test and Tissue Adhesive
02:37

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Published on: January 30, 2026

A 10-Year Comprehensive, Single-Center, Retrospective Analysis on Juxtapleural Nodules: Insights into Classification

Isabelle C Pappas1,2, Quincy A Hathaway1, Hubert A Gbate1,3

  • 1Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Diagnostics (Basel, Switzerland)
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Juxtapleural nodules are rarely concerning for malignancy, but vigilance is needed, especially in patients with a history of cancer. This study highlights real-world radiologist assessment patterns for these common findings.

Keywords:
intrapulmonary lymph nodesjuxtapleural nodulesmalignancyperifissural nodulesretrospective studythoracic imaging

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A 3D Digital Model for the Diagnosis and Treatment of Pulmonary Nodules
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Published on: May 19, 2023

Area of Science:

  • Radiology
  • Thoracic Imaging
  • Oncology

Background:

  • Juxtapleural and perifissural nodules are common findings on thoracic imaging.
  • They are typically presumed benign and often represent intrapulmonary lymph nodes.
  • Evaluation of their prevalence, clinical context, and management is crucial.

Purpose of the Study:

  • To evaluate the prevalence, clinical context, and management of juxtapleural nodules.
  • To assess factors associated with concern for malignancy in these nodules.
  • To understand real-world radiologist assessment and management patterns.

Main Methods:

  • Retrospective, single-center study analyzing radiology reports from 2015-2024.
  • Natural language processing used to identify reports with juxtapleural nodules.
  • Analysis of 85,435 unique patient encounters, with a focus on 659 cases concerning for malignancy.

Main Results:

  • Fewer than 1% (659/85,435) of juxtapleural nodules raised concern for malignancy.
  • Patients with concerning nodules were older and more likely to have a prior malignancy history.
  • Malignant nodules can mimic benign perifissural morphology on initial imaging.

Conclusions:

  • While most juxtapleural nodules are benign, a small subset warrants further evaluation.
  • Patients with a history of malignancy are at higher risk for concerning nodules.
  • Findings reflect radiologist concern and management in clinical practice, not definitive malignancy rates.