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Related Concept Videos

Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

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Related Experiment Video

Updated: Jun 13, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Predictive Model for Critical Illness Infection in Hospitalized Children with RSV Infection: A Retrospective Study.

Xingfeng Cheng1, Sha Wei1, Jinquan Xia2

  • 1Intensive Care Unit, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430074, China.

Diagnostics (Basel, Switzerland)
|June 12, 2026
PubMed
Summary

Predicting critical respiratory syncytial virus (RSV) pneumonia in children is crucial. Elevated interleukin-6 (IL-6), creatine kinase-MB (CK-MB), serum bilirubin excretion (SBE), and neutrophil percentage help identify high-risk infants.

Keywords:
critical illnesspredictive modelrespiratory syncytial virusrisk factor

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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
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An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

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Related Experiment Videos

Last Updated: Jun 13, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay
09:14

An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

Published on: January 26, 2019

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Respiratory syncytial virus (RSV) is a major cause of pediatric hospitalizations.
  • Predictors for severe RSV illness remain poorly understood.
  • Early identification of at-risk children is essential for timely intervention.

Purpose of the Study:

  • To identify risk factors for critical RSV pneumonia in children.
  • To develop a predictive model for critical RSV illness.
  • To improve early risk assessment and clinical decision-making.

Main Methods:

  • Retrospective analysis of 12,035 children hospitalized with RSV.
  • Inclusion of 30 critically ill children and 90 non-critical controls.
  • Multivariable logistic regression and nomogram development using identified predictors.

Main Results:

  • Four independent predictors of critical illness were identified: IL-6, CK-MB, SBE, and neutrophil percentage.
  • The developed nomogram showed excellent predictive discrimination (AUC = 0.921).
  • The model demonstrated strong calibration and clinical utility across various risk thresholds.

Conclusions:

  • Elevated IL-6, CK-MB, neutrophil percentage, and SBE are key indicators of critical RSV infection in children.
  • A nomogram incorporating these biomarkers offers a reliable tool for early risk stratification.
  • This predictive model can aid clinicians in managing pediatric RSV cases.