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Frailty Syndrome and Depressive Symptoms in Patients with Ischemic Heart Disease

Kristina Krivoshapova1, Daria Tsygankova1, Anastasia Neeshpapa1

  • 1Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo 650002, Russia.

Diagnostics (Basel, Switzerland)
|June 12, 2026
PubMed

Insights

This study found a significant link between frailty syndrome and depressive symptoms in patients with ischemic heart disease (IHD). Frail IHD patients were more likely to experience depression, highlighting a crucial connection.

Area of Science:

  • Cardiology
  • Geriatrics
  • Psychiatry

Background:

  • Ischemic heart disease (IHD) is a leading cause of morbidity and mortality.
  • Frailty syndrome and depressive symptoms are common in older adults and can negatively impact health outcomes.
  • The relationship between frailty and depression in IHD patients requires further investigation.

Purpose of the Study:

  • To evaluate the association between frailty syndrome and depressive symptoms in a cohort of patients with ischemic heart disease (IHD).

Main Methods:

  • A single-center cross-sectional study involving 169 IHD patients undergoing elective percutaneous coronary intervention.
  • Frailty was assessed using the European PRISMA-7 questionnaire (score ≥3 indicating high probability of frailty).
  • Depressive symptoms were evaluated using the 15-item Geriatric Depression Scale (GDS-15).

Main Results:

  • The prevalence of frailty was 52.7%, and high probability of depressive symptoms was observed in 19.5% of IHD patients.
  • Depressive symptoms were significantly more prevalent in frail patients compared to non-frail patients.
  • Frail IHD patients had 2.913 times higher frequency of depressive disorders (p=0.010) and a direct positive correlation between frailty and depression scores (ρ=0.392, p<0.001).

Conclusions:

  • A significant association exists between frailty syndrome and depressive symptoms in patients with ischemic heart disease.
  • Frailty may increase the risk and severity of depressive symptoms in IHD patients.
  • These findings underscore the importance of screening for frailty and depression in IHD management.

Keywords:
GDS-15 geriatric depression scalePRISMA-7 questionnairedepressive symptomsfrailty syndromeischemic heart disease

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