Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the neuroprotective power of mitochondrial transfer in orofacial inflammatory pain through ER membrane remodeling.

Cell reports·2026
Same author

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease.

Frontiers in cell and developmental biology·2025
Same author

Causal network between periodontitis and systemic inflammation: Triangulating evidence from Mendelian randomization and sequencing datasets.

Journal of periodontology·2025
Same author

Highly hydrophilic and dispersed TiO<sub>2</sub> nano-system with enhanced photocatalytic antibacterial activities and accelerated tissue regeneration under visible light.

Journal of nanobiotechnology·2023
Same author

Unloading of occlusal force aggravates alveolar bone loss in periodontitis.

Journal of periodontal research·2022
Same author

Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation.

Journal of periodontal research·2021

Related Experiment Video

Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Protonated Defect-Engineered Carbon Nitride Enables Bio-Interface-Enhanced Photodynamic Antibacterial Activity with

Ran Li1, Guixin Zhu1, Junchi Dong1

  • 1State Key Laboratory of Oral Diseases & National Center for Stomatology, West China School, Sichuan University, Chengdu 610041, China.

Materials (Basel, Switzerland)
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

A novel protonated defect-engineered carbon nitride nano-system (PVCN) shows promise for treating periodontitis. This material effectively kills bacteria and reduces inflammation and bone loss under visible light, offering a non-antibiotic approach.

Keywords:
graphitic carbon nitrideperiodontitisphotodynamic antibacterial therapyprotonation

More Related Videos

Animal Model of Implant-Associated Infections in Mice
07:02

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Light-Induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction
05:33

Light-Induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction

Published on: July 26, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Animal Model of Implant-Associated Infections in Mice
07:02

Animal Model of Implant-Associated Infections in Mice

Published on: June 27, 2025

Light-Induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction
05:33

Light-Induced In Situ Transmission Electron Microscopy for Observation of the Liquid-Soft Matter Interaction

Published on: July 26, 2022

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Periodontology

Background:

  • Periodontitis is a prevalent inflammatory disease linked to biofilms, necessitating novel non-antibiotic antibacterial treatments.
  • Current therapies face challenges in effectively managing periodontitis-associated bacterial infections.

Purpose of the Study:

  • To develop and evaluate a protonated defect-engineered graphitic carbon nitride nano-system (PVCN) for visible light photodynamic antibacterial therapy.
  • To investigate PVCN's efficacy against periodontopathic bacteria and its therapeutic potential in an experimental periodontitis model.

Main Methods:

  • Fabrication of PVCN via defect engineering and protonation of graphitic carbon nitride.
  • Assessment of PVCN's photodynamic activity, ROS generation, and antibacterial efficacy against *Staphylococcus aureus* and *Escherichia coli* under visible light.
  • Evaluation of PVCN's effect on bacterial biofilms, membrane integrity, and in a ligature-induced mouse periodontitis model.

Main Results:

  • PVCN exhibited enhanced visible light absorption and ROS production.
  • PVCN demonstrated over 95% bactericidal efficiency against *S. aureus* and *E. coli*, disrupting biofilms and damaging bacterial membranes.
  • In vivo studies showed PVCN reduced bacterial load, inflammation, and alveolar bone loss in a mouse periodontitis model.

Conclusions:

  • PVCN is a promising photodynamic antibacterial material for periodontitis treatment.
  • Defect engineering and surface protonation of carbon nitride enhance antibacterial efficacy.
  • Bio-interface regulation is a viable strategy for developing advanced antibacterial nanomaterials.