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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...

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Updated: Jun 13, 2026

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

Skin Regeneration in Diabetic Rats Using Gold Nanoparticles-Bioactive Glass Oil-in-Water Cream.

Sorin Marian Mârza1, Robert Cristian Purdoiu1, Adrian Valentin Potârniche1

  • 1Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 400372 Cluj-Napoca, Romania.

Materials (Basel, Switzerland)
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

A novel cream containing gold nanoparticles and bioactive glass accelerated wound closure in diabetic rats. While macroscopic healing occurred in 14 days, histological analysis indicated inflammation, suggesting further research is needed for complete dermal regeneration.

Keywords:
bioactive glassesdiabetic woundgold nanoparticlestissue regeneration

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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
11:13

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

Published on: April 7, 2016

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Diabetic Wound Healing

Background:

  • Diabetes mellitus significantly impairs chronic wound healing, increasing infection risk and complications.
  • Developing effective treatments for diabetic wounds is a critical medical challenge.
  • Accelerating wound regeneration in diabetic patients requires innovative biomaterials.

Purpose of the Study:

  • To evaluate the efficacy of a Sepigel 305® cream with gold nanoparticles-bioactive glass in promoting diabetic wound healing in rats.
  • To assess the histopathological changes and regeneration stages following treatment.

Main Methods:

  • Induction of diabetes mellitus in rats.
  • Application of a paraffin-based oil-in-water cream containing spherical gold nanoparticles-bioactive glass to induced wounds.
  • Macroscopic observation of wound closure.
  • Histopathological evaluation of tissue regeneration and inflammation.

Main Results:

  • Wounds treated with the experimental cream achieved macroscopic closure within 14 days.
  • Histological examination revealed persistent inflammatory processes, indicating incomplete deep dermal healing.
  • The 14-day macroscopic closure is considered a successful outcome for diabetic wound management, reducing infection risk.

Conclusions:

  • The Sepigel 305® cream demonstrates potential in accelerating macroscopic wound closure in diabetic models.
  • Further investigation is warranted to ensure complete dermal regeneration and resolution of inflammation.
  • The cream's ability to achieve timely macroscopic closure offers a promising strategy for managing diabetic wounds and preventing complications.