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Tomato Yellow Leaf Curl Virus Reprograms Polyamine Metabolism in Bemisia tabaci MED to Enhance Viral DNA Accumulation
Zitong Sang1, Haolin Han1, Fangfang Qi1
1State Key Laboratory of Agricultural and Forestry Biosecurity, MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China.
Abstract:
Tomato yellow leaf curl virus (TYLCV) is a major plant pathogen that spreads worldwide through persistent circulative transmission by Bemisia tabaci. During transmission, TYLCV crosses several physiological barriers in the insect vector, evading immune defenses and altering host metabolic pathways to facilitate viral accumulation. Polyamines, essential for maintaining nucleic acid stability and promoting cellular processes, are known to play a critical role in viral accumulation. However, their role in TYLCV accumulation within B. tabaci is not well understood. Here, we demonstrate that TYLCV infection leads to significant alterations in polyamine levels in B. tabaci, with polyamine availability positively affecting viral DNA accumulation. Polyamine availability leads to higher viral loads and suppresses the expression of immune and MAPK signaling genes. These findings provide new insights into virus-vector and metabolic interactions underlying viral persistence in insect vectors.
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