Related Experiment Video
Updated: Jun 13, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Daphmacropomines A-E: Five Daphniphyllum Alkaloids from Daphniphyllum macropodum Miq
Lili Xu1,2, Zhenpeng Niu1,2, Yu Zhang1,2
1State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
None:
Five new Daphniphyllum alkaloids, daphmacropomines A-E (1-5), were isolated from Daphniphyllum macropodum Miq. and structurally characterized. Compound 1 is an unprecedented Daphniphyllum alkaloid that features a unique 6/9/7/5/5 ring with a rare N-nitroso group. Compound 2 is the second Daphniphyllum alkaloid featuring a highly rearranged 6/6/6/7/5/6-fused skeleton. Compounds 3 and 4 are new yuzurimine-type alkaloids, and their structures were determined by extensive techniques including HRESIMS, NMR, ECD, and single-crystal X-ray. A plausible biosynthetic pathway for 1-4 is proposed. Furthermore, compounds 3 and 4 can induce lysosomal biogenesis and promote autophagic flux.
More Related Videos
Related Concept Videos
Other Algae
Physical Properties of Amines
Antifungal Agents
Diversity of Protists II

