Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Functionalized Cytisine Squaramides: Synthesis, Structural Elucidation, and Co-Crystallization.

Anna K Przybył¹, Alona Mintianska¹, Adam Huczyński¹

¹Department of Medical Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.

Molecules (Basel, Switzerland)

|June 12, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Low-Dimensional Silver(I) Coordination Polymers Based on a Flexible Dithione Ligand: Anion-Dependent Structures and Iodine Capture.

Langmuir : the ACS journal of surfaces and colloids·2026

Same author

Access to Cyclic Monensin Derivatives via a Four-Component Ugi Reaction.

The Journal of organic chemistry·2026

Same author

Potential Role of Exosomes in the Pathogenesis, Diagnosis, and Treatment of Ovarian Cancer.

Cancers·2026

Same author

Visible-light photocatalytic synthesis of imidazole-2-thiones in water using cobalt phthalocyanine.

RSC advances·2026

Same author

Multifunctional Humidity and Chemosensitive Thiazolothiazole-Based Metal-Organic Framework Sensor.

ACS applied materials & interfaces·2026

Same author

Synthesis, Topological, and Biological Studies of a Novel One-Dimensional Hg(II) Coordination Polymer With Antibacterial and Anticancer Potentials.

Bioinorganic chemistry and applications·2026

Researchers synthesized novel cytisine-squaramide-amino acid hybrids. Unexpected hydrolysis led to the discovery of their unique supramolecular assembly, enabling optimized purification and characterization for future applications.

Area of Science:

Organic Chemistry
Supramolecular Chemistry
Medicinal Chemistry

Background:

Cytisine derivatives are explored for medicinal applications.
Squaramide compounds are known for molecular recognition.
Combining these scaffolds presents synthetic challenges.

Purpose of the Study:

To synthesize novel bifunctional cytisine-squaramide derivatives with amino acid moieties.
To investigate and overcome challenges in their synthesis and purification.
To characterize the resulting compounds and explore their properties.

Main Methods:

Chemical synthesis of cytisine-squaramide conjugates.
Co-crystallization and single-crystal X-ray diffraction for structural elucidation.
Spectroscopic techniques (NMR, MS) and computational studies (DFT) for characterization.

Keywords:

amino acids co-crystals crystal structure cytisine derivatives squaramide squaric acid

More Related Videos

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

Published on: September 28, 2022

Main Results:

Unexpected hydrolysis of ester intermediates formed poorly soluble amido-acid byproducts.
Co-crystallization revealed the supramolecular nature of these byproducts.
Optimized purification strategies yielded pure cytisine-squaramide-amino acid derivatives (Cyt-SQ-OH).

Conclusions:

The study highlights the interplay of reactivity, solubility, and supramolecular assembly in these hybrids.
A robust platform for developing multifunctional conjugates was established.
Potential applications in medicinal chemistry, molecular recognition, and materials science are indicated.