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Chitosan-Curcumin Bioactive Platforms: Mechanistic Synergy, Antimicrobial Performance, and Design Principles for

Moorthy Maruthapandi^1,2, John H T Luong³

¹Department of Chemistry, Bar-Ilan University, Ramat-Gan 52900, Israel.

|June 12, 2026

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Chitosan-curcumin systems offer dual-action benefits for chronic wounds, combining chitosan

Area of Science:

Biomaterials Science
Wound Healing
Antimicrobial Agents

Background:

Chronic and infected wounds present challenges due to microbial persistence, biofilm formation, and inflammation.
Curcumin possesses antimicrobial, anti-inflammatory, and antioxidant properties but suffers from poor solubility and bioavailability.
Chitosan, a polysaccharide, offers antimicrobial activity, mucoadhesion, and serves as a versatile biomaterial platform.

Purpose of the Study:

To reframe chitosan-curcumin systems as dual-function bioactive platforms for wound management.
To explore the synergistic therapeutic outcomes of integrating chitosan and curcumin for wound healing.
To examine structure-function relationships and solubility enhancement strategies for chitosan-curcumin biomaterials.

Main Methods:

Keywords:

Mechanistic synergy antimicrobial and antifungal activity artificial intelligence-guided formulation biofilm disruption chitosan–curcumin systems multifunctional biomaterials nanoparticle delivery platforms polymicrobial infections solubility and bioavailability enhancement wound healing

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Review and critical examination of existing literature on chitosan-curcumin systems for wound healing.
Analysis of mechanistic contributions of both chitosan and curcumin to therapeutic effects.
Evaluation of factors influencing release kinetics, stability, cytocompatibility, and curcumin solubility.

Main Results:

Chitosan disrupts microbial membranes and supports tissue regeneration; curcumin modulates inflammatory pathways and microbial targets.
Integrated systems demonstrate multimodal antimicrobial activity, enhanced biofilm disruption, and coordinated wound healing.
Structure-function relationships (e.g., chitosan molecular weight, crosslinking) and solubility strategies impact efficacy.

Conclusions:

Chitosan-curcumin systems act as multifunctional platforms, leveraging the properties of both components for enhanced wound therapy.
Design principles for next-generation biomaterials should integrate antimicrobial activity with immune modulation and tissue repair.
Future directions include exploring antibiotic synergy, antifungal applications, and AI-driven material design.