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Updated: Jun 13, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
New Insights Into Cranial Base Ontogeny in Modern Humans Through Morphometric Analysis
Amaëlle Sourbé1, Mathilde Savignat2, Frédéric Santos1
1Univ. Bordeaux, CNRS, MCC, PACEA, UMR 5199, Pessac, France.
Objectives:
The cranial base is located at the interface between the face, the brain, and the vertebral column. Understanding its growth is essential for elucidating key aspects of craniofacial development, neurodevelopment, and locomotor function. This study aims to examine the developmental trajectories of the three cranial fossae, anterior, middle, and posterior, in terms of both size and shape.
Materials And Methods:
203 CT scans of individuals aged from birth to 15 years were segmented and analyzed. Traditional morphometric analyses based on linear measurements were first conducted to assess changes in length and width during growth. Geometric morphometric methods were applied to investigate shape variation, using a template of 32 anatomical landmarks and two curves of semi-landmarks.
Results:
Growth of the cranial base followed a rapid phase from 0 to 2 years and a slower growth until adolescence. Transverse dimensions generally reach adult proportions earlier than anteroposterior lengths. The posterior fossae exhibit pronounced anteroposterior and transverse expansion. Shape analyses reveal coordinated changes of fossae boundaries, including reorientation of the petrous temporal bones and increased curvature of the sphenoid wings. Strong allometric relationships and morphological integration are observed during the initial rapid growth phase. Sexual dimorphism has a statistically significant but moderate effect on cranial base fossae shape during ontogeny.
Discussion:
The cranial base exhibits biphasic growth, early-integrated shape changes, and later modularization, reflecting coordinated cranial and brain development. These patterns provide a reference for comparative studies in primates and highlight the importance of cranial base development for neurocranial and facial morphogenesis.
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