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Updated: Jun 13, 2026

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
Published on: September 9, 2022
Severe Abdominal Pain as a Prominent Clinical Manifestation of Anti-DPPX Autoimmune Encephalitis: A Case Report and
Difang Shi1, Haohao Wu2, Baogang Huang2
1Department of Thoracic Surgery I, The Third Affiliated Hospital of Kunming Medical University, Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan, Kunming, Yunnan, China.
Background:
Anti-dipeptidyl-peptidase-like protein 6 encephalitis (DPPXE) is an exceptionally rare form of autoimmune encephalitis characterized by a highly heterogeneous clinical phenotype.
Methods:
In this study, we report a Chinese patient presenting with severe abdominal pain as a prominent symptom; furthermore, we conducted a systematic review and analysis of 125 cases of DPPXE (including the present case).
Results:
This rare case presented with severe abdominal pain as a prominent symptom. We comprehensively summarized the clinical presentations, patterns of recurrence, and therapeutic responses of DPPXE. Notably, by comparing the clinical characteristics of DPPXE cases reported in China with those from other regions, we found some differences in disease presentation, suggesting potential racial or geographic variability.
Conclusion:
Our findings may provide up-to-date and comprehensive insights into the pathophysiology and clinical course of this rare disorder from multiple perspectives.
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