Related Experiment Video
Updated: Jun 13, 2026
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Hypertriglyceridemia‑Induced Acute Pancreatitis Compared With Non-Hypertriglyceridemia Acute Pancreatitis: A
Zahra Farhangiyan1,2, Leila Moradi1,2, Mehrdad Vaziri1
1Department of Internal Medicine, School of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
Background And Aims:
Hypertriglyceridemia-induced acute pancreatitis (HTGAP) is a distinct clinical subtype of acute pancreatitis (AP), but comparative data remain limited. This study aimed to compare risk factors, disease severity, and clinical outcomes between patients with HTGAP and non-HTGAP.
Methods:
A single-center retrospective case-control study was conducted using medical records of patients diagnosed with AP who were admitted to Imam Hospital (Ahvaz, Iran) between May 2020 and May 2025. Patients were categorized into HTGAP (n = 150) and non-HTGAP (n = 150) groups. Demographic data, severity scores, clinical complications, and length of hospital stay were compared between the two groups.
Results:
HTGAP was associated with significantly higher rates of complications, including acute respiratory distress syndrome, acute peripancreatic fluid collection, sepsis, acute necrotizing pancreatitis, pancreatic pseudocyst, walled-off or infected pancreatic necrosis, and renal failure (p < 0.05). HTGAP patients were younger and had higher body mass index than non-HTGAP patients (p < 0.001). They also had significantly higher mean Ranson (3.18 vs. 2.53), 24-h Acute Physiology, Chronic Health Evaluation II (APACHE II) (9.78 vs. 6.88), and modified computed tomography severity index (MCTSI) scores (7.08 vs. 4.54), as well as longer hospital stays (9.44 vs. 5.00 days), compared with non-HTGAP patients (p < 0.001). No in-hospital mortality occurred.
Conclusion:
HTGAP was associated with a more severe clinical profile and higher complication rates than non-HTGAP, highlighting the need for early recognition and careful management. Interpretation of these findings is limited by the retrospective single-center design and absence of multivariable adjustment.
More Related Videos
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Related Concept Videos
01:25Acute Pancreatitis I: Introduction
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:21Acute Pancreatitis II: Pathophysiology
01:25Chronic Pancreatitis I: Introduction
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...