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Related Concept Videos

Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Renewal of Skin Epidermal Stem Cells

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Related Experiment Videos

Unveiling a ceRNA Network Involving IL-8 and TNF-α in Active Generalized Vitiligo by Multi-Omics Integration.

Kang Ge1,2,3, Yilu Zhao4, Ruzhi Zhang1

  • 1Department of Dermatology and STD, The Second Affiliated Hospital of Wannan Medical College, Wuhu, 241000, People's Republic of China.

Immunotargets and Therapy
|June 12, 2026
PubMed
Summary

This study reveals a new competing endogenous RNA (ceRNA) network in active generalised vitiligo (AGV) by integrating proteomic and transcriptome data. Key inflammatory cytokines IL-8 and TNF-α are significantly upregulated in AGV patients.

Keywords:
active generalized vitiligocompeting endogenous RNAinterleukin-8proteomicswhole-transcriptome sequencing

Related Experiment Videos

Area of Science:

  • Dermatology and Immunology
  • Genomics and Bioinformatics
  • Molecular Biology

Background:

  • Active generalised vitiligo (AGV) is an autoimmune condition causing progressive melanocyte loss.
  • The molecular underpinnings of AGV, especially non-coding RNA interactions with proteomic changes, require further elucidation.
  • Understanding these mechanisms is crucial for developing targeted therapies.

Purpose of the Study:

  • To systematically identify key regulatory networks and molecular alterations in AGV.
  • To integrate proteomic and whole-transcriptome data for a comprehensive analysis.
  • To uncover novel molecular pathways involved in AGV pathogenesis.

Main Methods:

  • Whole blood samples from AGV patients and healthy individuals were analyzed using data-independent acquisition mass spectrometry (DIA-MS) and whole transcriptome sequencing (WTS).
  • Bioinformatic analyses identified differentially expressed proteins (DEPs), mRNAs, lncRNAs, circRNAs, and miRNAs.
  • Co-expression and competing endogenous RNA (ceRNA) networks were constructed and validated experimentally.

Main Results:

  • Significant alterations were found in 15 DEPs, 669 DEmRNAs, 258 lncRNAs, 29 miRNAs, and 44 circRNAs in AGV.
  • Functional enrichment highlighted involvement in chemokine signaling and lysosomal pathways.
  • A core ceRNA network was established, involving specific lncRNAs, circRNAs, and miRNAs, potentially modulating inflammatory responses. Key hub genes like CXCL8 were identified.

Conclusions:

  • Integrated multi-omics analysis revealed a novel ceRNA network in AGV.
  • Significant upregulation of pro-inflammatory cytokines IL-8 and TNF-α was confirmed in AGV patients.
  • These findings offer new insights into AGV's post-transcriptional regulation and inflammatory pathways, suggesting potential therapeutic targets.