Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extended endoscopic transnasal orbital decompression for dysthyroid optic neuropathy: efficacy and prognostic factors.

BMC ophthalmology·2026
Same author

A Selective-Transport Elastomeric Coating Regulating Hierarchical Solid Electrolyte Interphase for Low-Temperature Lithium-Metal Batteries.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Recovery of Platinum Group Metals from Spent Automotive Catalysts: A Review of Processes and Challenges.

Materials (Basel, Switzerland)·2026
Same author

Maturation of HIV-1 neutralizing antibodies in a germinal center conditional expression mouse model.

PLoS pathogens·2026
Same author

Advanced Glycation End Products delay diabetic wound healing by OSR2/SPRR1B signaling in keratinocyte's proliferation and differentiation.

Canadian journal of diabetes·2026
Same author

Diverse germline-targeting HIV Env immunogens select for distinct mutations in the same knock-in mice B cell receptors.

Nature communications·2026
Same journal

Keratocystoma of the Parotid Gland: A Systematic Review of Clinicopathologic Characteristics.

Laryngoscope investigative otolaryngology·2026
Same journal

Endoscopic Sealing With a PGA Sheet to Reduce Scarring After Vocal Fold Mucosal Resection.

Laryngoscope investigative otolaryngology·2026
Same journal

Comparison of Manual Versus Robot-Assisted Piston Prosthesis Placement and Crimping in a 3D-Printed Temporal Bone Model.

Laryngoscope investigative otolaryngology·2026
Same journal

Age-Dependent Decline in Tonsillectomy and Adenoidectomy During the COVID-19 Pandemic in Japan: A Nationwide Longitudinal Analysis of NDB Open Data.

Laryngoscope investigative otolaryngology·2026
Same journal

Tumor Growth Rate in Head and Neck Squamous Cell Carcinoma: A Scoping Review.

Laryngoscope investigative otolaryngology·2026
Same journal

Quality of Allergic Rhinitis Content Across Social Media Platforms.

Laryngoscope investigative otolaryngology·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

High Radiological Severity in CRSwNP Is Associated With a Mixed Type 2/Type 3 Epithelial Inflammatory Signature.

Guangfu Xu1, Ming Tian1, Kanghua Wang1

  • 1Department of Otolaryngology The Seventh Affiliated Hospital of Sun Yat-Sen University Shenzhen China.

Laryngoscope Investigative Otolaryngology
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Severe chronic rhinosinusitis with nasal polyps (CRSwNP) shows a mixed Type 2/Type 3 inflammatory profile linked to high disease severity. This suggests distinct molecular subtypes in CRSwNP patients with extensive sinus opacification.

Keywords:
Lund–Mackay scorechronic rhinosinusitis with nasal polypseosinophil infiltrationepithelial remodelingtype 2 inflammationtype 3 inflammation

More Related Videos

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Related Experiment Videos

Last Updated: Jun 13, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

Area of Science:

  • Immunology
  • Otolaryngology
  • Pathology

Background:

  • Severe chronic rhinosinusitis with nasal polyps (CRSwNP) presents a significant clinical challenge, often resisting standard treatments.
  • The underlying inflammatory mechanisms driving CRSwNP severity are not fully understood, hindering targeted therapy development.

Purpose of the Study:

  • To investigate the inflammatory profiles associated with disease severity in CRSwNP.
  • To correlate clinical and histopathological findings with molecular inflammatory markers.

Main Methods:

  • Prospective recruitment of 38 CRSwNP patients and 10 healthy controls.
  • Stratification of CRSwNP patients into low (Lund-Mackay Score [LMS] ≤12) and high (LMS >12) severity groups.
  • Analysis of clinical data, polyp tissue histology, and gene expression of inflammatory markers via RT-qPCR.

Main Results:

  • High LMS CRSwNP patients exhibited greater clinical burden, including higher symptom scores and peripheral eosinophil counts.
  • Histopathology revealed extensive tissue remodeling in high LMS patients, with basement membrane thickening and mixed eosinophilic/neutrophilic infiltration.
  • Molecular profiling showed elevated Type 2 and Type 3 inflammatory markers (e.g., IL-5, IL-13, CXCL2, IL-8) in the high LMS group.

Conclusions:

  • Severe CRSwNP (high LMS) is characterized by a mixed Type 2/Type 3 epithelial inflammatory signature.
  • Co-activation of Type 3 pathways with Type 2 responses correlates with severe tissue remodeling in CRSwNP.
  • High radiological scores in CRSwNP may indicate distinct molecular heterogeneity and specific inflammatory pathways driving disease.