Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 13, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

Functional and Metabolic Adaptations of Blood Flow Restriction Exercise in Rats and Post-surgical Patients.

Andin Fosam1,2, Susana Castelo Branco Ramos Nakandakari1,2, Matthew Dworkowitz2

  • 1Department of Internal Medicine, School of Medicine, Yale University, PO Box 208026, New Haven, CT 06520 USA.

Medrxiv : the Preprint Server for Health Sciences
|June 12, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Delayed Surgical Treatment of Pediatric and Adolescent Medial Meniscus Posterior Root Tears Is Associated With Increased Odds of Medial Tibiofemoral Compartment Cartilage Injury: A Multicenter Study.

The American journal of sports medicine·2026
Same author

Joint-Specific and Cross-Joint Strength Profiles in Relation to Maximal Soccer Kicking Speed.

Life (Basel, Switzerland)·2026
Same author

Implementation and evaluation of a dual task interprofessional education program: a mixed methods study.

Physiotherapy theory and practice·2026
Same author

Accuracy of Voluntary Force Modulation During the Isometric Mid-Thigh Pull.

Sports (Basel, Switzerland)·2026
Same author

Concomitant Lateral Meniscal Tears in Pediatric and Adolescent Patients Undergoing Combined Medial Meniscal Ramp Lesion Repair and Anterior Cruciate Ligament Reconstruction Are Frequently Missed on MRI, Are Often Vertical or Root Tears, and Are Usually Repaired: A Multicenter Study.

Orthopaedic journal of sports medicine·2026
Same author

Clinical Outcomes After Medial Meniscal Ramp Lesion Repair and Anterior Cruciate Ligament Reconstruction in Pediatric and Adolescent Patients: A Multicenter Study With a Mean Follow-up of 5 Years.

Orthopaedic journal of sports medicine·2026

Blood flow restriction exercise (BFR-E) improves muscle mass and strength. The benefits stem from tissue-specific adaptations, not acute systemic metabolic changes, in both rats and humans.

Area of Science:

  • Exercise Physiology
  • Metabolomics
  • Muscle Biology

Background:

  • Blood flow restriction exercise (BFR-E) is increasingly used for muscle hypertrophy and strength.
  • Systemic and intramuscular responses to BFR-E remain poorly understood.
  • A novel rat model for BFR-E was developed to investigate these responses.

Purpose of the Study:

  • To characterize the functional and metabolic effects of acute and chronic BFR-E in rats.
  • To investigate the acute systemic metabolic response to BFR-E in post-surgical humans.
  • To establish a translational framework for BFR-E research.

Main Methods:

  • Developed an in vivo rat model for BFR-E.
  • Utilized metabolomic analysis (rats and humans) and transcriptomic analysis (rats).
Keywords:
ACL reconstructionACL surgeryblood flow restrictionrehabilitationresistance exercise

More Related Videos

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

Related Experiment Videos

Last Updated: Jun 13, 2026

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
06:32

Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats

Published on: June 28, 2019

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

  • Assessed muscle mass, maximal strength, and systemic/intramuscular metabolites.

    • Main Results:

    • Chronic BFR-E increased muscle mass and strength in rats.
    • Acute BFR-E altered glycolysis and redox metabolites; chronic BFR-E affected amino acid and TCA cycle metabolites in rats.
    • Muscle-specific transcriptomic changes correlated with morphological adaptations in rats.
    • No significant systemic metabolic alterations were observed in humans following acute BFR-E.

    Conclusions:

    • BFR-E benefits are likely due to repeated, tissue-specific adaptations rather than acute systemic metabolic shifts.
    • Findings in rats regarding acute systemic responses were mirrored in humans.
    • The study provides a conserved, translational model for investigating BFR-E mechanisms.