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Low T3 syndrome and short-term outcomes in patients with acute decompensated heart failure: A retrospective
Noorussaba Arfeen1, Devendra Kumar Sinha1, Kaushal Kishore1
1Department of General Medicine, Patna Medical College and Hospital (PMCH), Patna, Bihar, India.
Abstract:
Acute decompensated heart failure (ADHF) drives frequent hospitalizations with high short-term morbidity/mortality, yet low triiodothyronine (T3) syndrome characterized by unexplained low serum free T3 remains understudied as a prognostic marker in resource- limited ADHF settings. Therefore, it is of interest to assess the prevalence of low T3 and its association with in-hospital mortality, length of stay and 30-day readmission in 115 ADHF patients. Low T3 syndrome affected 40.9% (47/115) of patients, who exhibited higher in- hospital mortality (25.5% versus 7.4%, p=0.006), longer stays (9.8±3.6 versus 6.9±2.4 days) and greater 30-day readmissions (34.3% versus 15.9%) than normal T3 controls. Multivariate analysis confirmed that low T3 was an independent predictor of mortality (adjusted OR 3.42, 95% CI 1.28-9.15, p=0.014) after adjusting for age, ejection fraction and creatinine. Thus, we show low T3 syndrome as a prevalent, actionable prognostic biomarker for risk stratification and targeted intervention in resource-constrained ADHF management.
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