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Cross-reactivity

Cross-reactivity

Diversity of Antigen Receptors

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Special Features of Adaptive Immunity

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Related Experiment Video

Updated: Jun 13, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Revised Adaptive Immune Receptor Data in the Immune Epitope Database.

Lonneke Scheffer¹, Eve M Richardson¹, Randi Vita¹

¹Center for Vaccine Innovation, La Jolla Institute for Immunology, La Jolla, San Diego, CA, USA.

Biorxiv : the Preprint Server for Biology

|June 12, 2026

Summary

This summary is machine-generated.

The Immune Epitope Database (IEDB) improved its receptor data quality and search functions. This enhances bioinformatics analysis and data integration for immune receptor research.

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Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

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Last Updated: Jun 13, 2026

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing

Published on: March 15, 2019

Area of Science:

Immunology
Bioinformatics
Computational Biology

Background:

The Immune Epitope Database (IEDB) is a vital resource for immune epitope and receptor data.
Manual curation of extensive receptor data from numerous references has led to nomenclature inconsistencies.
These inconsistencies pose challenges for computational analysis and user queries.

Purpose of the Study:

To revise the IEDB receptor data standardization and validation pipeline.
To improve data quality and consistency for immune receptors.
To enhance the IEDB web interface for better user experience and data accessibility.

Main Methods:

Revised the IEDB receptor data standardization and validation pipeline.
Flagged and corrected inaccuracies in receptor data, including anomalous receptors from over 800 studies.
Updated the IEDB web interface with new search and data export features.

Main Results:

Achieved greater conformity in the receptor dataset through consistent gene nomenclature and harmonized CDR sequence delimitation.
Expanded the IEDB web interface to include direct receptor search, V/J gene and species options, and Adaptive Immune Receptor Repertoire (AIRR) data export.
Successfully flagged anomalous receptors from over 800 studies for re-curation.

Conclusions:

Improved receptor data quality simplifies bioinformatics analyses.
Enhanced data consistency facilitates integration of IEDB data into cross-repository resources like the AIRR Knowledge Commons.
The updated IEDB resource offers improved accessibility and utility for researchers studying immune receptors and epitopes.