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  1. Home
  3. Aptamer-functionalized Swcnt Optical Sensors For Selective And Robust Dopamine Detection In Physiological Media.
  1. Home
  3. Aptamer-functionalized Swcnt Optical Sensors For Selective And Robust Dopamine Detection In Physiological Media.

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Aptamer-Functionalized SWCNT Optical Sensors for Selective and Robust Dopamine Detection in Physiological Media.

Maria Celina Stefoni1,2, Hanan Yafai1, Amelia K Ryan1

  • 1The City College of New York, Biomedical Engineering, New York, NY 10031.

ACS Applied Nano Materials
|June 12, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

We developed novel single-walled carbon nanotube (SWCNT) sensors using aptamers for highly selective dopamine detection. These sensors show robust performance in complex biological fluids, advancing neurological disorder monitoring.

Keywords:
carbon nanotubescerebrospinal fluiddopaminefluorescenceneurotransmitter

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Monitoring dopamine is crucial for diagnosing neurological disorders.
  • Existing methods face challenges in complex biological environments.
  • Single-walled carbon nanotubes (SWCNTs) offer unique optical properties for sensing.

Purpose of the Study:

  • To design and evaluate SWCNT-based near-infrared fluorescent sensors for dopamine detection.
  • To improve sensor selectivity and robustness in biological samples.
  • To compare the performance of different aptamer-SWCNT sensor constructs.

Main Methods:

  • Rational design of SWCNT-aptamer hybrids for dopamine recognition.
  • Evaluation of sensor performance in buffer, complex media, and artificial cerebrospinal fluid (aCSF).
  • Assessment of sensor constructs with varying passivation agents, including bovine serum albumin (BSA).

Main Results:

  • BSA-passivated aptamer-SWCNT sensors demonstrated superior selectivity for dopamine over similar molecules.
  • These sensors exhibited an increased magnitude of response compared to non-selective (GT)10-SWCNT constructs.
  • Dynamic ranges of 30-200 nM were observed within five minutes in various media.

Conclusions:

  • Aptamer-SWCNT sensors provide a selective and robust method for optical dopamine detection.
  • These sensors outperform non-selective ssDNA-SWCNT approaches in complex biological settings.
  • The developed sensors hold promise for improved neurological disorder diagnosis and monitoring.