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Culture Methods to Determine the Limit of Detection and Survival in Transport Media of Campylobacter Jejuni in Human Fecal Specimens
Published on: March 10, 2020
Clinical Characteristics of Campylobacter Bacteremia in Pediatric Population
Lee Galmor1, Aviv Sever2,3, David Levy4
1Department of Pediatrics A, Schneider Children's Medical Center of Israel, Petah Tiqva, Israel.
Insights
Pediatric Campylobacter bacteremia is rare, often affecting immunocompromised children. Despite severe underlying conditions, outcomes are usually favorable, with macrolides as the preferred treatment.
Area of Science:
- Pediatric Infectious Diseases
- Bacteriology
- Clinical Microbiology
Background:
- Campylobacter infection commonly causes pediatric gastroenteritis.
- Pediatric bacteremia due to Campylobacter is infrequently reported.
- Understanding risk factors and outcomes in pediatric Campylobacter bacteremia is crucial.
Purpose of the Study:
- To describe the clinical experience with Campylobacter bacteremia in a pediatric population.
- To identify patient characteristics, common species, and treatment outcomes.
- To evaluate the frequency of Campylobacter bacteremia in a tertiary care setting.
Main Methods:
- Retrospective study over 16 years at a tertiary-affiliated pediatric medical center.
- Inclusion of all pediatric patients diagnosed with Campylobacter bacteremia.
- Data collection on demographics, underlying conditions, clinical presentation, species, and outcomes.
Main Results:
- 37 pediatric patients with Campylobacter bacteremia were identified.
- 81% of patients had severe underlying medical conditions (e.g., malignancy, immunodeficiency).
- Campylobacter jejuni was the most common species; most isolates were susceptible to macrolides. Outcomes were generally favorable.
Conclusions:
- Campylobacter bacteremia is uncommon in children, more frequent in immunocompromised individuals.
- Fever and gastrointestinal symptoms are common presentations.
- Macrolides are effective treatments for pediatric Campylobacter bacteremia, even in immunocompromised patients.
Abstract:
Campylobacter infection in children is a common bacterial illness that mostly causes gastroenteritis and typically presents with diarrhea that may or may not be bloody, emesis, or abdominal pain. However, pediatric cases of bacteremia are rarely reported. Our objective was to report our tertiary center experience with Campylobacter bacteremia in a pediatric population. This 16-year retrospective study was performed at a tertiary-affiliated pediatric medical center. Data were collected from all patients with Campylobacter bacteremia during the study period. We identified 37 pediatric patients with Campylobacter bacteremia. Most children (n = 30, 81%) had severe underlying medical conditions, including malignancy and primary immunodeficiency. Only 7 (18.9%) children were previously healthy. The median age was 6.8 years, and children with severe underlying medical conditions were older than previously healthy children (9 vs. 1.2 years, P = .02). Most children present with fever and/or gastrointestinal symptoms. Campylobacter jejuni was the most common species (n = 30, 81%), and most isolates tested for antibiotic susceptibility were susceptible to macrolides. While one child was hospitalized in the intensive care unit because of septic shock, the outcome for all children was favorable. Campylobacter bacteremia is an uncommon complication of Campylobacter infection in children and has been reported more frequently among immunocompromised patients. Most children present with fever or gastrointestinal symptoms. Even in this predominantly immunocompromised population, the outcome is generally favorable, with most cases resolving without complications. Macrolides remain the antibiotic of choice for Campylobacter infections, including bacteremia.
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