Development of Nanostructured Lipid Carrier (NLC)-Patch for Jambolan (Syzygium cumini Linn.) Seed Extract Delivery

The application of nanotechnology to drug delivery has the potential to improve drug therapeutic efficacy. Jambolan (Syzygium cumini Linn.) is a natural source that provides several pharmacological activities, including antioxidant, antidiabetic, and anticancer properties. However, the use of Jambolan seeds remains limited due to the lack of delivery systems. Therefore, this study aimed to develop a nanocarrier, Nanostructured Lipid Carrier (NLC), containing Jambolan Seed Extract (JSE) incorporated into a patch.

Three formulations with various surfactant concentrations of Cremophor RH 40 and Span 80 were prepared, followed by characterization, including particle size, Polydispersity Index (PI), and zeta potential. The selected formulation was evaluated for its morphology and antioxidant activity. Moreover, the NLC-JSE patch was prepared, and the physical properties, weight uniformity, thickness, folding endurance, and stability were evaluated.

The selected NLC-JSE formulation showed particle sizes of 183.10 ± 12.97 nm, PI of 0.58 ± 0.06, and zeta potential of -31.41 ± 1.20 mV. The IC50 of NLC-JSE (3.10 + 0.12 mg/L) was significantly less than that of ascorbic acid as a standard (12.52 + 0.69 mg/L). The patch produced the required properties.

A desirable NLC-JSE patch was produced. NLC-JSE with a 3:3 ratio of Cremophor RH 40 and Span 80 met the required characteristics. NLC-JSE provided a higher potential antioxidant than the standard.

The resulting NLC-JSE patch exhibited the required properties and was physically and chemically stable during storage.