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Substrate-Selective Inhibition of the SARS-CoV-2 Papain-Like Protease: Inhibition of Hydrolysis of Human Over Viral

Sakshi Sharma1, Peter A C Wing2, Wojtek Trede1

  • 1Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 12, 2026
PubMed

Keywords:
SARS‐CoV‐2 main protease / MproSARS‐CoV‐2 papain‐like protease / PLprodeubiquitinase / DUBinterferon‐stimulated gene 15 / ISG15mass spectrometryprotease inhibitionsubstrate‐selective inhibitionubiquitinvirus‐host interactions

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