Related Experiment Video
Updated: Jun 13, 2026

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
Published on: September 27, 2024
A Zinc-Coordinated Glycopolymer for Inhibiting Bacterial Toxins in Management of Acute Pneumonia
Siyuan Huang1, Yuqing Hu1, Junyao Yang2
1Key Laboratory of Functional Polymer Materials (Ministry of Education), Institute of Polymer Chemistry, Tianjin Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin 300071, China.
Abstract:
Bacterial toxins play a critical role in infections by compromising host defenses, causing host cell death, and inducing excessive immune activation, ultimately leading to severe tissue damage and increased mortality. To combat both the pathogen and its associated toxins, this study developed a bacteria-targeting zinc-coordinated glycopolymer designed to deliver antisense oligonucleotides (ASOs) and absorb lipopolysaccharides (LPS). The functional polymer enhances Pseudomonas aeruginosa internalization efficiency through galactose-mediated bacterial surface interaction. By delivering multiple ASOs, the nanoparticle enables the dual suppression of bacterial growth and quorum sensing, exhibiting potent antibacterial activity. Furthermore, zinc ions coordinated within the glycopolymer impart the ability to bind and adsorb LPS, thereby mitigating the toxin-induced damage to host cells. In a murine model of acute pneumonia, this approach significantly improved survival rates and reduced pro-inflammatory cytokine levels. Consequently, pulmonary inflammation was suppressed, bacterial toxin-induced damage was alleviated, and tissue integrity was preserved. This synergistic strategy of combined sterilization and toxin neutralization offers a novel and synergistic therapeutic approach to combating bacterial infections.
More Related Videos
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
06:05Using the Overlay Assay to Qualitatively Measure Bacterial Production of and Sensitivity to Pneumococcal Bacteriocins
Published on: September 30, 2014
Related Concept Videos
Inhibitors of Gram-positive Cell Wall Synthesis
Pneumonia IV: Management
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
Pneumonia V: Nursing management and Prevention
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
Atypical Pneumonia
Gene Regulation in Microbial Communities: Quorum Sensing
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...