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  3. Phosphate Disorders In Cancer.
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  3. Phosphate Disorders In Cancer.

Related Experiment Video

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

Phosphate Disorders in Cancer.

Joyita Bharati1, Raad B Chowdhury2,3,4, Chandan Krushna Das5

  • 1Department of Internal Medicine, Massachusetts General Hospital, Massachusetts, USA.

Kidney360
|June 12, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Phosphate disorders, including hypophosphatemia and hyperphosphatemia, are common in cancer patients. Understanding their mechanisms is key for effective management, especially with new cancer treatments.

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Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
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Published on: May 10, 2024

Area of Science:

  • Oncology
  • Nephrology
  • Endocrinology

Background:

  • Phosphate disorders are prevalent in cancer patients, causing significant morbidity.
  • Mechanisms are influenced by tumor biology, cancer therapies, and cellular changes.
  • Malignancies like multiple myeloma (MM) and tumor-induced osteomalacia impact phosphate levels.

Purpose of the Study:

  • To review the mechanisms of hypophosphatemia and hyperphosphatemia in cancer care.
  • To outline management strategies for phosphate disorders in the current era of novel cancer therapies.

Main Methods:

  • Literature review focusing on phosphate homeostasis in oncology.
  • Analysis of mechanisms including drug-induced renal phosphate wasting and tumor lysis syndrome.

Main Results:

  • Hypophosphatemia can result from MM, tumor-induced osteomalacia, and drug-induced renal phosphate wasting (e.g., platinum-based therapy, TKIs).
  • Hyperphosphatemia is often linked to tumor lysis syndrome, potentially causing hypocalcemia and acute kidney injury.
  • A stepwise diagnostic approach is crucial for appropriate treatment.

Conclusions:

  • Phosphate disorders require careful evaluation in cancer patients.
  • Management strategies must consider the underlying malignancy and treatment modalities.
  • Timely intervention is essential to mitigate morbidity associated with these disorders.