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Aerocavin Is an Antibiotic with Potent and Specific Anti-Neisserial Activity

Gleb Pishchany1, Kyra E Fryling2, Vineetha Vasukuttan1

  • 1Center for Therapeutics, Toxicology, and Devices, RTI International, Durham, North Carolina 27709, United States.

ACS Infectious Diseases
|June 12, 2026
PubMed
Summary

A new natural product, aerocavin, shows high potency against the sexually transmitted infection gonorrhea. This compound targets bacterial RNA polymerase and may offer a microbiome-sparing treatment option.

Keywords:
NeisseriaRNA polymeraseaerocavingonorrheanarrow-spectrum antibioticsripostatin

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