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Cardiac Rehabilitation Improves Outcomes After Thoracic Aortic Aneurysm Repair
Chiemi Yamazaki1, Atsuko Nakayama2, Junko Sakamoto3
1Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Department of Cardiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
JACC. Asia
|June 12, 2026
Summary
Cardiac rehabilitation (CR) after thoracic aortic aneurysm (TAA) surgery significantly lowers major adverse cardiovascular events and all-cause mortality. This benefit was observed even in former smokers, highlighting CR
Area of Science:
- Cardiology
- Vascular Surgery
- Rehabilitation Medicine
Background:
- Cardiac rehabilitation (CR) is established for ischemic heart disease and heart failure.
- Effectiveness of CR in thoracic aortic aneurysm (TAA) patients post-surgery is not well-defined.
- TAA repair surgery requires comprehensive post-operative care to improve patient outcomes.
Purpose of the Study:
- To determine the impact of outpatient CR on major adverse cardiovascular events (MACE).
- To assess the effect of CR on all-cause mortality following open TAA repair.
- To analyze CR's role in TAA patient recovery and long-term prognosis.
Main Methods:
- Retrospective cohort study of 1,710 patients undergoing open TAA repair (2003-2015).
- Comparison between a CR group (n=419) and a non-CR group (n=1,193).
- Propensity score matching used to control for baseline differences; primary outcomes: MACE and all-cause mortality.
Main Results:
- The CR group showed significantly lower MACE (HR: 0.58) and all-cause mortality (HR: 0.59) post-matching.
- Five-year estimated all-cause mortality was 7.5% for CR vs. 12.3% for non-CR.
- CR benefit persisted in former smokers, who had higher overall mortality risk (HR: 2.69).
Conclusions:
- Outpatient CR post-TAA surgery is linked to reduced MACE and mortality.
- CR demonstrates a positive impact on survival even for TAA patients with a history of smoking.
- Integrating CR into post-TAA surgical care may improve long-term cardiovascular outcomes.
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