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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Cardiac Rehabilitation Improves Outcomes After Thoracic Aortic Aneurysm Repair

Chiemi Yamazaki1, Atsuko Nakayama2, Junko Sakamoto3

  • 1Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan; Department of Cardiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

JACC. Asia
|June 12, 2026
PubMed

Insights

Cardiac rehabilitation (CR) after thoracic aortic aneurysm (TAA) surgery significantly lowers major adverse cardiovascular events and all-cause mortality. This benefit was observed even in former smokers, highlighting CR

Area of Science:

  • Cardiology
  • Vascular Surgery
  • Rehabilitation Medicine

Background:

  • Cardiac rehabilitation (CR) is established for ischemic heart disease and heart failure.
  • Effectiveness of CR in thoracic aortic aneurysm (TAA) patients post-surgery is not well-defined.
  • TAA repair surgery requires comprehensive post-operative care to improve patient outcomes.

Purpose of the Study:

  • To determine the impact of outpatient CR on major adverse cardiovascular events (MACE).
  • To assess the effect of CR on all-cause mortality following open TAA repair.
  • To analyze CR's role in TAA patient recovery and long-term prognosis.

Main Methods:

  • Retrospective cohort study of 1,710 patients undergoing open TAA repair (2003-2015).
  • Comparison between a CR group (n=419) and a non-CR group (n=1,193).
  • Propensity score matching used to control for baseline differences; primary outcomes: MACE and all-cause mortality.

Main Results:

  • The CR group showed significantly lower MACE (HR: 0.58) and all-cause mortality (HR: 0.59) post-matching.
  • Five-year estimated all-cause mortality was 7.5% for CR vs. 12.3% for non-CR.
  • CR benefit persisted in former smokers, who had higher overall mortality risk (HR: 2.69).

Conclusions:

  • Outpatient CR post-TAA surgery is linked to reduced MACE and mortality.
  • CR demonstrates a positive impact on survival even for TAA patients with a history of smoking.
  • Integrating CR into post-TAA surgical care may improve long-term cardiovascular outcomes.
Abstract

Keywords:
MACEcardiac rehabilitationmortalitypostoperative carethoracic aortic aneurysm

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