An approach for detecting hemodynamic parameters in the carotid arterial system based on the priori relationship
Jin Wang1,2, Yong-Jiang Li1,2, Yu-Yuan Zhang1,2
1Institute of Cardio-Cerebrovascular Medicine, Central Hospital of Dalian University of Technology, Dalian, 116033, People's Republic of China.
Insights
This study presents a novel framework for non-invasive vascular monitoring using common carotid artery (CCA) waveforms and modeling. It enables real-time assessment of hemodynamic parameters for early cardiovascular risk detection.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Medical Imaging Analysis
Background:
- Cardio-cerebrovascular diseases are leading global causes of death, largely due to atherosclerosis.
- The common carotid artery (CCA) is crucial for understanding disease progression, with local hemodynamics (e.g., wall shear stress) and systemic indices (e.g., peripheral resistance) being key indicators.
- Current imaging methods for quantifying these parameters are expensive, complex, and not suitable for continuous monitoring.
Purpose of the Study:
- To develop a non-invasive framework for continuous vascular monitoring by integrating clinical CCA waveforms with a priori modeling.
- To enable real-time estimation of local and systemic hemodynamic indices, including wall shear stress, resistance, and compliance.
- To support early cardiovascular risk assessment through accessible vascular health monitoring.
Main Methods:
- Developed a framework integrating clinically acquired CCA pressure and flow velocity waveforms with a priori modeling.
- Established a pressure-arterial radius (p-r) relationship to estimate dynamic radius changes from continuous pressure signals.
- Utilized a distributed-lumped parameter hybrid model to compute local and systemic hemodynamic indices.
Main Results:
- The p-r model accurately reproduced arterial radius waveforms and demonstrated temporal stability over five weeks.
- The hybrid model provided real-time estimates of local parameters (flow rate, WSS) and systemic indices (resistance, compliance).
- Sensitivity analysis confirmed the influence of elastic parameter variations on hemodynamic outcomes.
Conclusions:
- The developed framework offers a promising approach for continuous, non-invasive vascular monitoring.
- This method facilitates real-time assessment of hemodynamic parameters, aiding in early cardiovascular risk stratification.
- The integration of waveform analysis and modeling provides a cost-effective and accessible tool for vascular health assessment.
Abstract:
Cardio-cerebrovascular diseases are the leading causes of death worldwide, primarily driven by atherosclerosis. The common carotid artery (CCA) offers valuable insight into disease progression, as local hemodynamic parameters such as wall shear stress (WSS) influence plaque formation, while systemic indices like peripheral resistance reflect overall vascular health. Existing imaging-based approaches can quantify these measures but are costly, complex, and unsuitable for continuous monitoring. To address this, we developed a framework that integrates clinically acquired CCA waveforms with a priori modeling. By establishing a priori pressure-arterial radius (p-[Formula: see text]) relationship, dynamic [Formula: see text] changes were estimated directly from continuous p signals. This relationship, combined with p and flow velocity waveforms, enabled a distributed-lumped parameter hybrid model to compute both local and systemic hemodynamic indices. The p-[Formula: see text] model reliably reproduced [Formula: see text] waveforms and exhibited temporal stability across repeated measurements over five weeks. Coupled with the hybrid model, it provided real-time estimates of local parameters such as flow rate and WSS, as well as systemic indices including resistance and compliance. Sensitivity analysis underscored the impact of variations in elastic parameters on outcomes. This approach supports continuous, non-invasive vascular monitoring with promising potential for future applications in early cardiovascular risk assessment.
Related Concept Videos
01:21Sites for measuring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
01:23Assessment of blood pressure in brachial artery(two-step method)
01:28Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
01:17Measurement of Blood Pressure
01:15Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure: