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Updated: Jun 13, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Artificial Intelligence in Biomedical Scientific Publishing
Tomasz J Guzik1,2, Victor Aboyans3, Stefan Agewall4
1Editor-in-Chief of the Cardiovascular Research, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, United Kingdom.
Abstract:
Artificial intelligence is now embedded across the scientific research and publishing ecosystem, influencing discovery, analysis, knowledge translation, authorship, peer review, and editorial workflows. In cardiovascular and biomedical sciences, these developments offer substantial opportunities to accelerate knowledge generation, integrate complex datasets, and improve efficiency and consistency. At the same time, they introduce new risks related to bias, transparency, data integrity, and authorship responsibility, potentially endangering trust in the scientific record. This commentary examines the evolving role of AI in biomedical publishing, with particular attention to generative models and machine learning tools. We review both benefits and limitations, highlight risks such as fabricated content, biased outputs, and erosion of accountability, and discuss why traditional detection approaches are insufficient. Instead, we argue for a shift toward transparency, provenance, and enforceable human responsibility as the core principles guiding AI use, ensuring that AI strengthens rather than undermines scientific rigour and public trust. We outline practical expectations for authors, reviewers, editors, and publishers, with emphasis on reporting standards, reproducibility under rapidly evolving model versions, and the conflict-of-interest implications of AI tooling for the editorial process itself.
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