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Therapeutic Effects of Hemoperfusion in Treating Long-Acting Anticoagulant Rodenticide Poisoning

Jianguang Dong1, Bingling Yin2, Jieyi Wu3

  • 1Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.

Blood Purification
|June 12, 2026
PubMed
Abstract

Insights

Hemoperfusion effectively reduced rodenticide levels in poisoning patients. This blood purification method also shortened vitamin K1 therapy duration for brodifacoum poisoning.

Area of Science:

  • Toxicology
  • Emergency Medicine
  • Nephrology

Background:

  • Second-generation anticoagulant rodenticides pose life-threatening bleeding risks.
  • Limited effective treatments exist for severe rodenticide poisoning.
  • Evaluating hemoperfusion as a therapeutic option is crucial.

Purpose of the Study:

  • To assess the therapeutic efficacy of hemoperfusion in rodenticide poisoning.
  • To compare outcomes between hemoperfusion and non-hemoperfusion groups.
  • To analyze the impact on serum drug concentrations and treatment duration.

Main Methods:

  • Retrospective analysis of 115 patients with rodenticide poisoning (2014-2021).
  • Comparison of hemoperfusion (n=24) versus non-hemoperfusion (n=91) groups.
  • Analysis of clinical data, serum drug levels, hospital stay, and vitamin K1 therapy duration.

Main Results:

  • Hemoperfusion may accelerate blood toxin clearance.
  • Significantly reduced duration of vitamin K1 therapy in brodifacoum poisoning patients (P=0.044).
  • Hemoperfusion demonstrated effectiveness in reducing serum rodenticide concentrations.

Conclusions:

  • Hemoperfusion is an effective treatment for reducing serum rodenticide levels.
  • Hemoperfusion shortens vitamin K1 therapy duration in brodifacoum poisoning.
  • Hemoperfusion offers a valuable therapeutic strategy for anticoagulant rodenticide poisoning.
Keywords:
HemoperfusionLong-acting anticoagulant rodenticide poisoningMaintenance treatmentVitamin K1

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