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Related Experiment Video

Updated: Jun 14, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
07:35

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

Kidney Organoids: Disease Modeling and Clinical Implementations for Patient Benefit.

Elisa Gessaroli, Sara Donini, Jason A Wertheim

    Nephron
    |June 12, 2026
    PubMed
    Summary

    Human pluripotent stem cells (hPSCs)-derived kidney organoids offer a novel in vitro model for studying kidney diseases and drug toxicity. While powerful, further maturation is needed for broader applications in nephrology research.

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    Area of Science:

    • Nephrology
    • Stem Cell Biology
    • Regenerative Medicine

    Background:

    • Conventional experimental models inadequately replicate human kidney complexity.
    • Human pluripotent stem cells (hPSCs)-derived kidney organoids offer a 3D in vitro system for studying kidney development and disease.
    • Current organoids have limitations in structural and physiological complexity compared to native kidneys.

    Purpose of the Study:

    • To highlight the utility of kidney organoids in modeling inherited and acquired kidney disorders.
    • To discuss the application of kidney organoids in mechanistic research and drug nephrotoxicity testing.
    • To identify current limitations and future directions for enhancing kidney organoid models.

    Main Methods:

    • Utilizing hPSCs to generate kidney organoids.

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    Last Updated: Jun 14, 2026

    Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
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    Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

    Published on: February 17, 2023

    Generation of Human Kidney Tubuloids from Tissue and Urine
    08:34

    Generation of Human Kidney Tubuloids from Tissue and Urine

    Published on: April 16, 2021

    Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells
    07:22

    Generating Kidney Organoids in Suspension from Induced Pluripotent Stem Cells

    Published on: September 1, 2023

  • Employing transcriptomic, proteomic, imaging, and functional analyses.
  • Developing organoid-on-chip systems for improved maturation.

    • Main Results:

    • Kidney organoids successfully model genetic kidney diseases (cystic, ciliopathies, tubular, glomerular) and acquired conditions (damage, stress, nephrotoxicity).
    • These platforms allow mechanistic pathway investigation at the nephron segment level.
    • Methodological advances are improving organoid maturation and physiological relevance.

    Conclusions:

    • Kidney organoids represent a valuable human-based platform for nephrology research, particularly for disease modeling and nephrotoxicity screening.
    • Current limitations include immaturity, variable composition, and lack of integrated vasculature and urinary systems.
    • Future advancements in maturation and system integration are crucial for regenerative applications.