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Updated: Jun 14, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
The tissue-specific regulation of immunobiology by IL-17 signaling
Yang Li1, Shachi P Vyas1, Peter Draber2
1Division of Rheumatology and Clinical Immunology, Dept. of Medicine, University of Pittsburgh, Pittsburgh, USA.
Abstract:
IL-17 family cytokines are central regulators of tissue immunity. Here, we review recent advances in defining the cell- and tissue-specific activities of IL-17, emphasizing the signaling pathways engaged by IL-17 receptor (IL-17R) complexes and their associated downstream pathways. We highlight the intersecting transcriptional and posttranscriptional mechanisms that determine IL-17-driven responses and that underlie functional diversity across tissues. Last, we discuss emerging roles for IL-17 signaling in immunometabolism, neuroimmune interactions, cancer, and the latest approaches for targeted therapies.
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