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Updated: Jun 14, 2026
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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Relationships between glucose variability with white matter hyperintensity and cerebrovascular abnormalities
Cheng-Chieh Lin1,2,3, Chia-Ing Li1,2, Chiu-Shong Liu1,2,3
1School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Archives of Endocrinology and Metabolism
|June 12, 2026
Summary
Glucose variability (GV) in type 2 diabetes is linked to white matter hyperintensities and cerebrovascular issues. Genetically predicted GV shows a potential causal relationship with these brain abnormalities.
Area of Science:
- Neuroscience
- Endocrinology
- Genetics
Background:
- Glucose variability (GV) is a known predictor of stroke, cognitive impairment, and dementia in type 2 diabetes mellitus (T2DM).
- Limited evidence exists on the association between GV and white matter hyperintensity (WMH) or cerebrovascular abnormalities.
Purpose of the Study:
- To investigate the relationships between GV and WMH and cerebrovascular abnormalities.
- To utilize both epidemiological and Mendelian randomization (MR) approaches to explore these associations.
Main Methods:
- A cross-sectional study involving 2,247 patients with T2DM.
- Assessment of GV using measures like standard deviation, coefficient of variation, average real variability (ARV), and variability independent of the mean (VIM).
- Analysis of brain MRI for WMH and cerebrovascular abnormalities; MR used genetic proxies for GV.
Main Results:
- Genetically predicted FPG-VIM was associated with WMH (OR 1.17 [95% CI 1.08, 1.27]).
- Most genetically predicted GV measures were linked to cerebrovascular abnormalities, excluding FPG-ARV.
- 80 single-nucleotide polymorphisms served as genetic instruments for GV.
Conclusions:
- Genetically predicted GV is associated with WMH and cerebrovascular abnormalities.
- Findings support a potential causal link between GV and these brain abnormalities under MR assumptions.
