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Drug Dosing: Obese Patients

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Randomized Controlled Trial to Study the Acute Effects of Strength Exercise on Insulin Sensitivity in Obese Adults
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Exercise Snacks in Adults Living With Obesity: Protocol for a Randomized Feasibility Trial.

Seth F McCarthy1, Ella Harness1, Noah Mulkewich2

  • 1School of Health and Exercise Sciences, Faculty of Health and Social Development, University of British Columbia, Okanagan Campus, 3333 University Way, Kelowna, BC, V1V 1V7, Canada, 1 250-807-9876.

JMIR Research Protocols
|June 12, 2026
PubMed
Summary

Exercise snacks, short bursts of vigorous activity, show promise for improving fitness in adults with obesity. This pilot study assessed their feasibility and effectiveness in a 12-week trial.

Keywords:
behavior counsellingcardiorespiratory fitnessexerciseobesityphysical activity

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Area of Science:

  • Exercise Physiology
  • Obesity Research
  • Cardiometabolic Health

Background:

  • Rising global obesity rates present significant health and economic challenges.
  • Traditional exercise interventions face barriers like time constraints and lack of access for individuals with obesity.
  • Exercise snacks offer a novel approach to increase physical activity and improve health outcomes.

Purpose of the Study:

  • To determine the feasibility of a smartphone app-supported exercise snacks intervention for adults with obesity.
  • To assess the preliminary efficacy of exercise snacks in improving cardiorespiratory fitness and cardiometabolic markers.
  • To evaluate adherence and dropout rates in a pilot randomized clinical trial (RCT).

Main Methods:

  • A 12-week, 2-site parallel-arm RCT involving 80 inactive adults with obesity.
  • Participants were randomized to either exercise snacks (4x1-min vigorous bouts daily) or stretching/mobility exercises.
  • Interventions were delivered via a smartphone app with behavioral counseling and telephone support.

Main Results:

  • Recruitment for the pilot RCT began in July 2025, with 65 participants enrolled by March 2026.
  • Data analysis is pending completion of the trial, with results anticipated in winter 2027.
  • Feasibility will be assessed through recruitment, adherence, and dropout rates.

Conclusions:

  • This study will provide evidence on the feasibility of exercise snacks for inactive adults with obesity.
  • Preliminary effect size estimates for improving cardiometabolic health will be reported.
  • The findings will inform future RCT protocols for exercise snack interventions.