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Selenium nanoparticle-and quercetin-embedded nanofibrous mats for enhanced cutaneous wound healing
Hassan Maleki1, Kamyar Khoshnevisan2, Hadi Baharifar3
1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background:
Chronic skin wounds with delayed healing due to underlying disorders necessitate advanced dressings.
Objective:
Thus, this study aimed to develop a nanofibrous dressing loaded with selenium nanoparticles (Se NPs) and quercetin (Que) to accelerate the wound healing process. The combination was designed to exploit the complementary antioxidant and anti-inflammatory properties of Se NPs and quercetin, which together help modulate oxidative stress and promote tissue regeneration.
Methods:
First, Se NPs were synthesized, characterized, and co-loaded with quercetin into PVA/CS nanofibers via electrospinning. Their properties, antioxidant activity, and release profile were assessed, and wound healing was evaluated in a full-thickness rat model with histopathological validation.
Results:
The synthesized Se NPs demonstrated nanoscale dimensions with a uniform, spherical morphology. Electrospinning of PVA/CS nanofibers loaded with Se NPs and Que at 10 wt% (1:1 ratio) produced fibers with an average diameter of 312 ± 43 nm, exhibiting a ribbon-like structure without droplets or beads. The nanofibers exhibited high porosity, fluid absorption, and full wettability, with strong antioxidant activity and a sustained 72-hour release profile. Animal wound healing assessments demonstrated the highest healing rate and wound closure, averaging around 98%, after 14 days. Histopathological evaluations further confirmed the complete regeneration of skin layers and significant tissue repair.
Conclusion:
The Se NPs-quercetin nanofibrous mat shows strong potential as a multifunctional dressing for enhanced wound healing and skin regeneration.
