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A Simple Approach to Induce Experimental Autoimmune Neuritis in C57BL/6 Mice for Functional and Neuropathological Assessments
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Neuromelioidosis in a nutshell-Pattern and Endemicity

P Janet Preethi Philomina1, V C Sunitha1, S Adithan1

  • 1Department of Radiodiagnosis, JIPMER, Pondicherry, India.

Clinical Radiology
|June 12, 2026
PubMed

Insights

NeuroMelioidosis, a rare brain infection caused by Burkholderia pseudomallei, requires prompt imaging diagnosis. Recognizing characteristic imaging patterns, especially corticospinal tract involvement, is key for effective treatment and improved patient survival.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Accurate neuroimaging is vital for diagnosing neurological symptoms unresponsive to standard treatment.
  • Burkholderia pseudomallei causes NeuroMelioidosis, a rare but serious infection with distinct brain and spinal cord manifestations.
  • The condition is endemic in tropical regions, including parts of South India.

Purpose of the Study:

  • To illustrate the critical role of imaging in identifying NeuroMelioidosis.
  • To emphasize characteristic imaging patterns, particularly corticospinal tract involvement.
  • To improve diagnostic accuracy and guide targeted antibiotic therapy.

Main Methods:

  • Pictorial essay format with case illustrations.
  • Review of imaging findings in NeuroMelioidosis.
  • Discussion of differential diagnoses for similar imaging presentations.

Main Results:

  • Imaging can identify characteristic patterns of brain and spinal cord involvement in NeuroMelioidosis.
  • Corticospinal tract involvement is a specific and important imaging hallmark.
  • Awareness of geographical prevalence and imaging features aids diagnosis.

Conclusions:

  • Timely and accurate imaging diagnosis of NeuroMelioidosis is crucial for effective management.
  • Recognizing specific imaging patterns, like corticospinal tract involvement, is essential.
  • Improved diagnostic capabilities can lead to better patient outcomes through targeted therapy.

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