Related Experiment Video

Updated: Jun 14, 2026

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

Bundle implementation for reduction of central venous catheter associated bloodstream infections in pediatric

Hanna Clemente Rosenvald1, Luiza Duarte de Barros1, Hyan Bacelete2

  • 1Faculdade Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil.

Infection, Disease & Health
|June 12, 2026
PubMed

Insights

Catheter-associated bloodstream infections (CLABSI) in pediatric intensive care units (PICUs) were reduced by over 50% in most studies using care bundles. Further research is needed to confirm effectiveness.

Area of Science:

  • Healthcare-associated infections
  • Pediatric intensive care
  • Infection control

Background:

  • Catheter-associated bloodstream infections (CLABSI) are common in pediatric intensive care units (PICUs).
  • CLABSI are preventable and increase healthcare costs, length of stay, and mortality.
  • Care bundles are implemented globally to reduce CLABSI rates.

Purpose of the Study:

  • To evaluate and compare the effectiveness of various care bundles in reducing CLABSI rates in PICUs.
  • To analyze CLABSI rate reductions per 1000 catheter-days.

Main Methods:

  • Systematic review of 23 studies from multiple databases (PubMed, Embase, etc.).
  • Studies selected based on PRISMA guidelines.
  • Extracted CLABSI rates before and after bundle implementation; calculated percentage reductions.

Main Results:

  • Baseline CLABSI rates varied from 2.0 to 25.2 per 1000 catheter-days.
  • Post-intervention rates ranged from 0.7 to 14.3 per 1000 catheter-days.
  • Over 50% of studies reported >50% reduction in CLABSI rates; no study achieved zero CLABSI.

Conclusions:

  • Care bundles are associated with significant reductions in PICU CLABSI rates.
  • Consistent improvements suggest bundle effectiveness despite methodological weaknesses in most studies.
  • Randomized controlled trials are needed to determine the effect size of individual bundle components.
Abstract

Keywords:
Catheter-related infectionsCentral venous cathetersIntensive care unitsPatient care bundlesPediatricPrevention and control

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