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Updated: Jun 14, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

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Published on: June 18, 2018

Efficacy signals in a 12-week trial of clavulanic acid to decrease cocaine use.

Joya Maser1, Linda Callans1, Daohai Yu2

  • 1Department of Psychiatry, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.

Drug and Alcohol Dependence
|June 12, 2026
PubMed
Summary
This summary is machine-generated.

Clavulanic acid (CLAV) shows potential for treating cocaine use disorder (CUD), particularly in women. While not statistically significant overall, women using CLAV reported fewer cocaine use days and reduced withdrawal symptoms.

Keywords:
Clavulanic acidClinical trialCocaine cravingCocaine use disorders

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Urgent need for effective treatments for cocaine use disorder (CUD).
  • Clavulanic acid (CLAV), a clinical-stage medication, shows promise for CUD treatment.

Purpose of the Study:

  • To evaluate the efficacy and safety of clavulanic acid (CLAV) in treating cocaine use disorder (CUD).

Main Methods:

  • A 12-week outpatient study randomized 64 participants with CUD to receive either CLAV (500mg/day, escalating to 750mg/day) or placebo.
  • Dose escalation to 750mg/day occurred in week 5.

Main Results:

  • No statistically significant overall improvement in the CLAV group versus placebo.
  • Women in the CLAV group showed a significant reduction in cocaine use days starting week 4.
  • CLAV treatment reduced cocaine withdrawal symptoms in women compared to placebo over the first 3 weeks; no effects were observed in men.

Conclusions:

  • A signal suggests CLAV (500-750mg/day) may reduce cocaine use days in women with CUD.
  • Men with CUD did not benefit from CLAV at these doses.
  • CLAV was safe and well-tolerated; future research should explore optimal dosing for men and mechanisms in women.