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Published on: February 16, 2015
Chemoimmunotherapy enables adaptive strategies in locally advanced MSS colorectal cancer
Filippo Ghelardi1, Filippo Pietrantonio2
1Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Giacomo Venezian 1, 20133 Milan, Italy; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abstract:
Early exposure to checkpoint blockade restores immune-sensitivity in localized, immune-excluded cancers. In this issue of Med, Zhang et al. reported promising pathological activity of 3-month preoperative cadonilimab (bispecific anti-PD-1/CTLA-4 antibody) with modified FOLFOXIRI triplet intensive chemotherapy in patients with locally advanced MSS colorectal adenocarcinoma, hinting to new adaptive strategies of radiotherapy-sparing and organ preservation.1.
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