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Updated: Jun 14, 2026
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
Published on: April 19, 2024
Cystic fibrosis-associated inflammatory bowel disease: a case series and literature review
Antoine Rochereau1, Xavier Treton2, Anne Bourrier3
1CHU Rennes, Université Rennes, F-35000 Rennes, France.
Introduction:
The management of inflammatory bowel disease (IBD) in patients with cystic fibrosis (CF) at risk of respiratory failure and severe lung infection is poorly described. The objective of this study was to describe the phenotype and evolution of IBD associated with CF, as well as the efficacy and tolerance of IBD treatments.
Materials And Methods:
A national, multicentre, descriptive, retrospective study was conducted. The study included all adult patients with a confirmed diagnosis of CF and IBD identified across participating GETAID centres. Disease characteristics and outcomes were retrieved from patient charts.
Results:
A total of 10 cases with IBD associated with CF were identified (six male; median age at diagnosis, 32 years; 10 with Crohn's disease (CD)). In CF, the DeltaF508 mutation was predominant; nine patients had lung involvement, and all had exocrine pancreatic involvement. Disease location and behaviour at diagnosis were similar to those observed in the general IBD population. During follow-up, four patients underwent surgery (40%), and nine patients were treated with immunosuppressants or biologics, resulting in clinical remission for 50% and 66%, respectively. Two patients with severe CF co-colonised with Pseudomonas Aeruginosa and Staphylococcus aureus experienced severe lung infection.
Conclusion:
Patients with CF are more likely to have CD than ulcerative colitis. In patients with advanced CF, the potential infectious risks associated with IBD therapies require individualised assessment.
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